Malonic acid, dibromo-, diethyl ester
Diethyl dibromomalonate
CAS: 631-22-1
Molecular Formula: C7H10Br2O4
Malonic acid, dibromo-, diethyl ester - Names and Identifiers
| Name | Diethyl dibromomalonate |
| Synonyms | Ethyl dibromomalonate Diethyl dibromomalonate DIETHYL DIBROMOMALONATE Diethyl 2,2-dibromomalonate diethyl dibromopropanedioate Dibromomalonic acid diethyl ester dibromo-propanedioicacidiethylester Dibromo malonic acid, diethyl ester Malonic acid, dibromo-, diethyl ester 2,2-DIBROMO-MALONIC ACID DIETHYL ESTER Propanedioic acid, dibromo-, diethyl ester |
| CAS | 631-22-1 |
| EINECS | 211-151-9 |
| InChI | InChI=1/C7H10Br2O4/c1-3-12-5(10)7(8,9)6(11)13-4-2/h3-4H2,1-2H3 |
Malonic acid, dibromo-, diethyl ester - Physico-chemical Properties
| Molecular Formula | C7H10Br2O4 |
| Molar Mass | 317.96 |
| Density | 1.68 g/mL at 25 °C (lit.) |
| Boling Point | 140-143 °C/18 mmHg (lit.) |
| Flash Point | >230°F |
| Vapor Presure | 0.0126mmHg at 25°C |
| BRN | 1783879 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | n20/D 1.484(lit.) |
Malonic acid, dibromo-, diethyl ester - Risk and Safety
| Risk Codes | 34 - Causes burns |
| Safety Description | S20 - When using, do not eat or drink. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. |
| UN IDs | 1760 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29171900 |
| Hazard Class | 8 |
| Packing Group | III |
Malonic acid, dibromo-, diethyl ester - Reference Information
| use | diethyl dibromomalonate can be used as an intermediate in pharmaceutical synthesis. |
| preparation | using diethyl malonate and sodium bromide as raw materials, the reaction steps are as follows: diethyl malonate (0.160g,1mmol), sodium bromide (0.206g,2mmol), cuprous bromide (0.014g,0.1mmol), manganese acetate (1.89g,7mmol) and acetic acid (10 ml) are added to the reaction bottle to react at 60 ℃; TLC followed the reaction until it was completely completed. The crude product obtained after the reaction was separated by column chromatography (ethyl acetate: petroleum ether = 1:20) to obtain the target product diethyl dibromomalonate (yield 74%). |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Last Update：2024-04-09 02:00:01
